Brain Cancer is unique in that it is formed in the brain, an electrically active network. Decoding the electrical activity and networking of brain cancer cells is central to our understanding of this complex and devastating condition.
This project looks at discovering the secrets of the electrical activity of brain cancer cells, and how those cancer cells integrate within neural networks in living human tissue. The aim is to manipulate brain activity to understand what impact this has on the growth and spread of these cancers. In doing so, we hope to unveil a whole new category of therapeutic targets that address the electrical communication between neurons and cancer cells within the brain, which we believe is at the heart of the resistance of brain cancers to typical cancer therapies.
To our knowledge, there are no other groups pursuing this highly specialised area, which requires expertise in the functioning of normal neurons, and thus we are at the forefront of this new and important arm of brain cancer research.